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Treatment and Screening

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2021 STI Treatment Guidelines

The guidelines provide CDC’s most current evidence-based recommendations for preventing, diagnosing and treating people who have, or are at risk for, STIs. Includes regimens, evidence tables, wall chart, and pocket guide.

Recommendations for Providing

Quality STD Clinical Services (STD QCS)

Recommendations and tools intended to guide STD clinical practice standards in healthcare settings and optimize patient care. This is a companion piece to the 2021 STI Treatment Guidelines.

 Availability of STI Testing & Treatment Products

Updates on the availability of STI testing and treatment products.

Expedited Partner Therapy

Providing prescriptions or medications to the patient to take to his/her partner without the health care provider first examining the partner.

Laboratory Information

Guidance, specimen submission, and more.

Additional Resources

General STD treatment updates and resources, including Dear Colleague Letters, podcasts, and scientific articles.


STI Treatment Guide Mobile App


The new app is free and available for iPhone and Android devices.

Get the App

Additional Resources

General STD treatment updates and resources, including Dear Colleague Letters, podcasts, and scientific articles.


Injectable Syphilis Treatment Delivery: Considerations for STD Programs – A resource outlining best practices for designing and implementing an injectable syphilis delivery treatment program in a state or local health department. This toolkit was developed by the National Coalition for STD Directors in collaboration with CDC. (August 2023)


Mycoplasma genitalium (Mgen) Treatment Failure Registry – Healthcare providers and health departments can report Mgen treatment failures to the CDC. (December 12, 2022)


Suspected Gonorrhea Treatment Failure Consultation Form – Healthcare providers and health departments can report suspected gonorrhea cephalosporin treatment failure or any N. gonorrhoeae specimen with decreased cephalosporin susceptibility to the CDC. (December 12, 2022)


Doxy-PEP as an STI Prevention Strategy – Considerations for individuals and healthcare providers of gay or bisexual men or transgender women (July 27, 2022)


A Guide to Taking a Sexual History – This guide offers a framework for discussing sexual health issues to help complete the overall picture of your patient’s health.


Duty to Warn – “Duty to warn” is a legal concept that indicates possible liability for healthcare providers if no warning of possible harm is given in certain circumstances. This analysis discusses whether duty to warn applies to healthcare providers and STD diagnoses. (April 26, 2021)


STD Care and Prevention Guidance During Disruption of Clinical Services (September 8, 2020)


The Diagnosis, Management and Prevention of Syphilis: An Update and Review – A clinical guidance document for use in the diagnosis and management of syphilis. Based on content from the 2015 CDC STD Treatment Guidelines, and developed by the NYC Department of Health and Mental Hygiene Bureau of Sexually Transmitted Infections and the NYC STD Prevention Training Center. (March 2019)


National STD Curriculum – An online modular learning experience that helps users learn how to manage STDs. Free CME/CNE available. (November 1, 2017)

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